CP-TPP is a non-US transpacific free trade agreement. However, this is still one of the major free trade agreements in the world with Japan being the world's third-largest economy. Together with Industrial Revolution 4.0 (IR 4.0), it presents great opportunities and challenges for the Vietnamese economy. Developing high quality human resources is one of the key pillars of the Vietnamese economy if it is to seek the benefits of CP-TPP and IR 4.0. In fact, high quality human resources in Vietnam are very weak and fragmented. This paper will address high quality human resource development solutions in line with the real situation of the Vietnamese economy in the hope that it can help Vietnam achieve the maximum benefits provided by CP-TPP and IR 4.0.