The study poised to understand the impact of new pandemic on the transportation and logistics sector in Ghana. Data was gathered from 250 participants made of transport owners, drivers, mates and GPRTU personnel in Greater Accra and Central Regions of Ghana. The results from table 3 show that COVID-19 had negative effects on air, road and rail transportation in Ghana during the peak of pandemic. The responses however show that COVID-19 had a positive effect on the water/sea/ocean transportation. It was concluded that COVID-19 has greater impact on logistics and transport sectors in Ghana just any other country across the globe.