Vol. 6, Issue 2, Part F (2024)

Cellular senescence is a complex biological process involving the irreversible arrest of cell proliferation, often linked to aging, tissue dysfunction, and a variety of age-related diseases. The mechanistic target of rapamycin (mTOR) pathway plays a crucial role in regulating cellular metabolism, growth, and senescence, making it an attractive target for therapeutic interventions. Polyphenols, a group of bioactive compounds found in various plants, have demonstrated promising effects in modulating the mTOR pathway, thereby potentially mitigating the detrimental effects of cellular senescence. This review adopts a multidisciplinary approach to explore the intersection of polyphenols and mTOR signaling in the context of cellular senescence. A systematic overview of the current research on polyphenol-based interventions targeting the mTOR pathway is provided, focusing on their molecular mechanisms, efficacy in preclinical studies, and translational potential for human health. The objective is to elucidate how polyphenols could be utilized as natural mTOR inhibitors to reduce cellular senescence and associated pathologies. By understanding the relationship between polyphenols and mTOR signaling, this review aims to contribute to the development of novel, evidence-based therapeutic strategies for combating aging-related diseases.